Plague, Inc.'s prion game mode is a very demanding challenge, especially on the "brutal" difficulty level. Due to the slowness with which the disease infects the population and unleashes its effects, it will often happen that the search for a cure advances faster than your infection. By maximizing the infectivity rate and keeping the most severe symptoms to a minimum, you will have much higher chances of success. It will be a very difficult challenge and it may take many attempts to overcome it.
Steps
Part 1 of 4: Selecting the Genetic Code Changes
Step 1. Select "ATP Increase" as the DNA gene
This skill allows you to start the game with additional DNA and is important for getting your infection to start properly.
Step 2. Select "Genetic Imitation" as the mutation gene
This feature makes prion infection more difficult to cure and will help you tremendously in the later stages of the game.
Step 3. Select "Aquacito" as the traveler gene
Aquacito will help you infect Greenland, one of the hardest to reach places for infection.
Step 4. Select "Urbophile" as the environmental gene
This ability helps the prion break through closed borders by rapidly infecting major urban centers.
Step 5. Select "Synto-stasis" as the evolution gene
Synto-stasis reduces the cost of symptoms, allowing you to quickly reach the most useful ones. It makes the disease easier to cure, but you will only make it lethal at the last second, killing the entire population before a cure is discovered. This strategy involves rapidly developing a long list of symptoms.
Part 2 of 4: Starting the Infection
Step 1. Select Saudi Arabia, China or South Africa
They are the best countries to start a game in prion mode, as they allow for the fastest spread of the disease.
Step 2. Focus on the symptoms that facilitate the spread of the disease
Early in the game prioritize spreading symptoms, which are less expensive than transmission improvements. Develop the following symptoms as soon as possible:
- Rash.
- Nausea.
- Sweating.
- He retched.
- Cyst.
- Hypersensitivity.
- Abscesses.
- Cough.
- Pneumonia.
- Sneezing.
Step 3. Improve some transmission skills to be able to infect Greenland
Boosts the following three types of transmission to help the infection reach Greenland and Madagascar:
- Water 1.
- Air 1.
- Water 2.
Step 4. Upgrade some skills to be able to infect Greenland and other difficult nations
The following skills ensure that your illness reaches Greenland, the country most important to the success of your strategy, as well as other rich countries like Monaco and Sweden:
- Cold resistance 1.
- Cold resistance 2.
- Heat resistance 1.
- Drug resistance 1.
- Drug resistance 2.
- Genetic hardening 1.
- Genetic hardening 2.
Step 5. Undo evolutions not listed in the previous steps
If natural mutations develop, cancel them to prevent your disease from becoming too deadly or attracting too much attention. Additionally, you will receive a small DNA bonus.
Make sure you cancel all symptoms right away, otherwise the disease may be discovered before you have completed the preparations
Part 3 of 4: Increase Infectivity and Slow Down the Progress of Treatment
Step 1. Evolve some more severe symptoms to spread the infection
The symptoms listed below increase the infectivity of your disease and allow you to acquire more DNA:
- Pulmonary edema.
- Skin lesions.
Step 2. Evolve some symptoms to slow down the discovery of a cure
The following symptoms help slow down the search:
- Insomnia.
- Paranoia.
- Convulsions.
- Paralysis.
- Coma.
Step 3. Evolve your prion's special abilities
Use the following three skills to severely limit the progress of your cure:
- Neural atrophy 1.
- Neural atrophy 2.
- Neural atrophy 3.
Part 4 of 4: Infect the World and Become Deadly
Step 1. Evolve the Necrosis symptom
This symptom will start killing the sick, but not so quickly as to end the game. It also increases the likelihood of contagion.
Step 2. Evolve the Gene Shuffle Skill
This will slow down the search for a cure by at least a few percent.
Step 3. Evolve Genetic Reshuffle 2 when cure reaches 25%
Scientists will quickly approach a cure towards the end of the game, so slow their progress when they reach around 25%, before moving on to the final steps.
If you have a few DNA points left, you can skip Gene Scrambling 2. You should never use Gene Scrambling 3
Step 4. Wait for all nations to get infected
If it hasn't happened yet, you have to wait for every country in the world to get infected before turning your disease into a deadly machine.
Once the last nation is infected, wait for the number of infected to reach 10,000-15,000 before continuing
Step 5. Evolve Total organic collapse
Make sure the last country you infected reached at least 10,000-15,000 infected before evolving this symptom. You will start killing people very quickly.
Step 6. Evolve Dysentery
This symptom helps ensure that the disease continues to spread while killing the population.
To develop dysentery you must already have one of the symptoms of Diarrhea or Madness
Step 7. Evolve Hemorrhagic shock
This symptom increases the mortality rate of your disease as you progress towards the final stages of the game.
Step 8. Wait for the entire population to be infected and killed
If you were successful, the whole world should be infected in a short time and the sick should die shortly after. You can speed up the process by evolving other symptoms, or by purchasing Genetic Scrambling to slow down the cure if necessary.
